Corey S. Cutler, MD, MPH, FRCPC, Dana-Farber Cancer Institute

Final Thoughts: GVHD

July 30th 2021

All panelists provide their final thoughts on the current landscape and future directions in graft-vs-host disease (GVHD).

Steroid-Refractory Chronic GVHD

July 30th 2021

Sophie Paczesny, MD, PhD, provides an overview of the drug ibrutinib for use in steroid-refractory chronic graft-vs-host disease (GVHD). She elicits thoughts from the panelists on how they envision this drug being used.

Steroid-Refractory Acute GVHD

July 30th 2021

Richard Maziarz, MD, provides an overview of the drug ruxolitinib, which was recently approved for use in steroid-refractory acute GVHD (graft-vs-host disease). He leads a discussion on the results of REACH-1 and REACH-2 and the experiences of the other panelists in using this drug.

Steroid Refractory GVHD: Scope of the Problem

July 23rd 2021

Dr Chen provides an overview of the prevalence of steroid refractory GVHD and leads a discussion on how steroid refractory GVHD is defined.

Management of Chronic GVHD

July 23rd 2021

Dr Cutler leads a discussion on the approach to management of chronic GVHD and whether complete response is a realistic end point.

Management of Acute GVHD

July 16th 2021

Yi-Bin Chen, MD, leads a discussion on systemic treatment approaches being used currently for the management of acute graft-vs-host disease, as well as those being considered for the future.

Diagnosing & Staging of GVHD

July 16th 2021

Sophie Paczesny, MD, PhD, leads a discussion on diagnostic tests used in the setting of graft-vs-host disease and how patients are risk stratified. Whether organ biopsies are used routinely is also discussed.

GVHD Prophylaxis

July 9th 2021

Richard Maziarz, MD, highlights the fact that graft-vs-host disease (GVHD) is a T-cell disease and then outlines qualitative and quantitative mechanisms that are used to prophylactically target the alloreactive T-cell population. A calcineurin inhibitor combined with methotrexate is the currently accepted standard of care for GVHD prophylaxis. Panelists weigh in on the use of post-transplant cyclophosphamide (PTCy) for prevention of GVHD.

Immunopathology and GVHD Incidence

July 9th 2021

Yi-Bin Chen , MD, provides an overview of how the landscape graft-vs-host disease (GVHD) has evolved over the past 3 decades. Corey Cutler, MD, PhD, FRCPC, provides an overview of GVHD biology. Potential risk factors for development of acute and chronic GVHD are discussed.

Unmet Needs in GVHD

May 4th 2021

Challenges and unmet needs in steroid-refractory GVHD and advice to community oncologists for the optimal management of disease.

Emerging Therapies for Acute and Chronic GVHD

May 4th 2021

Novel agents in the pipeline for the treatment of acute and chronic GVHD are discussed.

Treatment for Steroid-Refractory Chronic GVHD

April 27th 2021

A review of treatment options for patients with chronic GVHD who don’t respond to steroid therapy and preliminary findings from the phase 3 REACH3 trial.

Treatment for Steroid-Refractory Acute GVHD

April 27th 2021

Defining steroid-refractory acute GVHD, treatment options for patients who don’t respond to steroid therapy, and a review of the REACH2 trial.

Initial Therapy in GVHD

April 20th 2021

Experts in hematology-oncology share insights on approaching initial treatment and the treatment goals for acute and chronic GVHD.

Role of GVHD Prophylaxis

April 20th 2021

A discussion on the role of prophylactic therapy for patients after transplant as well as available options for GVHD prophylaxis.

Diagnosis of Acute and Chronic GVHD

April 13th 2021

Hematologist-oncologists review the typical presentation and diagnosis of acute and chronic GVHD and define how severity is classified.

Overview of Graft-Versus-Host Disease

April 13th 2021

Corey S. Cutler, MD, MPH, FRCPC; Yi-Bin Chen, MD; and Haris Ali, MD, provide insight on the nature of graft-vs-host disease (GVHD) and common risk factors for acute and chronic GVHD.

Future Treatment Landscape of AML

March 15th 2021

Corey S. Cutler, MD, MPH, FRCPC; Adam Bagg, MD; Alexander E. Perl, MD, MS; Eunice S. Wang, MD; and Harry P. Erba, MD, PhD, share closing thoughts and emerging therapies on the horizon for the treatment of AML.

Maintenance Therapy Post-Transplant in AML

March 15th 2021

Patient selection for maintenance therapy post-allogeneic transplant in myeloid malignancies and thoughts on treatment of FLT3-mutated disease post-transplant with agents such as midostaurin.

Use of APR-246 and Oral HMAs in AML

March 8th 2021