Hematologic Oncology | Specialty

Next Steps in Mantle Cell Lymphoma

March 2nd 2021

MRD Assessment in Mantle Cell Lymphoma

March 2nd 2021

Novel Therapies in the Pipeline in Mantle Cell Lymphoma

March 2nd 2021

Dr. D'Angelo on Sequencing Therapies in Lymphoma

March 2nd 2021

Christopher R. D’Angelo, MD, discusses sequencing therapies for patients with lymphoma.

New Methods for MRD Testing Help to Predict Relapse Across Multiple Leukemia Subtypes

March 2nd 2021

Minimal residual disease has helped to predict relapse in numerous leukemia subtypes, with novel testing methods helping to identify the biomarker at a higher sensitivity than ever before.

BR Retains its Role in Frontline Waldenström Macroglobulinemia Despite the Utility of BTK Inhibitors

March 1st 2021

The treatment landscape of Waldenström macroglobulinemia is becoming increasingly complex with second-generation BTK inhibitors; however, the combination of bendamustine and rituximab remains the frontline standard of care for this patient population.

Martin Makes Sense of the Rapidly Evolving MCL Treatment Paradigm

March 1st 2021

As more options emerge in the mantle cell lymphoma paradigm, choosing among the agents available has become all the more challenging.

Immunotherapy Is on the Cusp of Major Breakthroughs in Multiple Myeloma

March 1st 2021

Immune therapy has evolved rapidly in multiple myeloma, and the field is on the verge of major improvements in outcomes.

A More Simplified Health Care System is Needed to Provide Value

March 1st 2021

Although scientific advances in hematology and oncology have been extraordinary, the US health care system faces significant challenges in ensuring that patients receive high-quality, cost-effective care.

Use of Omidubicel Therapy in Hematologic Malignancies

March 1st 2021

BMT CTN 1102 Study in High-Risk MDS

March 1st 2021

MRD Testing in R/R Follicular Lymphoma

March 1st 2021

Drs Caron A. Jacobson and Krish Patel comment on NGS (next-generation sequencing) and MRD (minimal residual disease) testing in relapsed/refractory follicular lymphoma.

Role of Rebiopsy in R/R Follicular Lymphoma

March 1st 2021

The rationale for rebiopsying patients who have relapsed/refractory follicular lymphoma and the types of molecular information that can be applied to treatment decisions.

DiNardo Describes Practical Considerations for the Management of Unfit Patients With AML

February 28th 2021

Several options have emerged for patients with acute myeloid leukemia who are not candidates to receive chemotherapy, with venetoclax-based regimens chief among them.

Targeted Therapies Dominate the Relapsed/Refractory CLL Paradigm

February 27th 2021

Targeted therapies have helped to improve responses in patients with relapsed chronic lymphocytic leukemia regardless of high-risk disease, although optimal sequencing and toxicity management need to be further explored to strengthen the utilization of these options.

FDA Approves Melphalan Flufenamide for Relapsed/Refractory Multiple Myeloma

February 27th 2021

The FDA has approved melphalan flufenamide for use in combination with dexamethasone in the treatment of select adult patients with relapsed/refractory multiple myeloma.

Early Successes and Remaining Challenges of Harnessing Natural Killer Cells for Cancer Therapy

February 27th 2021

Natural killer cells can offer several advantages over T cells for CAR therapy in that the former uses both a CAR dependent and independent mechanism for tumor eradication, has better safety, and off-the-shelf feasibility—all at a potentially lower cost.

Relapsed/Refractory DLBCL Undergoes Rapid Evolution With CAR T-Cell Therapy, ADCs, and Bispecific Antibodies

February 26th 2021

High-dose chemotherapy and transplant remains the second-line standard of care for the majority of patients with relapsed/refractory diffuse large B-cell lymphoma; however, CAR T-cell therapy and other novel agents, which have transformed the third-line setting, may offer alternative and more personalized second-line options in the coming years.

Raising the Standard Beyond Frontline R-CHOP in DLBCL

February 26th 2021

Rituximab plus CHOP is not a suitable frontline treatment regimen for all patients with diffuse large B-cell lymphoma, explained Andre H. Goy, MD, who specified that patients with a high-risk International Prognostic Index, elderly patients, and patients with high-risk molecular subtypes require alternative treatment.

Ianalumab/Ibrutinib Combo Shows Promising Activity in CLL

February 26th 2021

Kerry A, Rogers, MD, discusses the rationale behind the phase 1b study of VAY736 combined with ibrutinib in patients with chronic lymphocytic leukemia and the next steps for this research.