Hematologic Oncology | Specialty

The OncLive Hematology Oncology condition center page is a comprehensive resource for clinical news and expert insights on various hematologic malignancies, including leukemias, lymphomas, myeloproliferative neoplasms, multiple myeloma, and much more. This section features news articles, interviews in written and video format, and podcasts that focus on unmet needs, treatment advances, and ongoing research in hematologic cancers.

FDA Grants Abatacept Breakthrough Designation for Acute GVHD

December 5th 2019

The FDA has granted a breakthrough therapy designation for abatacept for the prevention of moderate-to-severe acute graft-versus-host disease in patients who have undergone hematopoietic stem cell transplants from unrelated donors.

Brentuximab Vedotin Combos Among Key Advances in Hodgkin, T-Cell Lymphoma

December 4th 2019

Alison J. Moskowitz, MD, discusses pivotal data for brentuximab vedotin in Hodgkin and T-Cell Lymphoma, as well as other ongoing developments in these paradigms.

FDA Panel to Review Application for Luspatercept in MDS

December 3rd 2019

The FDA’s Oncologic Drugs Advisory Committee has scheduled a hearing to review a supplemental Biologics License Application for luspatercept-aamt for use as a treatment for patients with myelodysplastic syndromes.

Dr. Stein on the Importance of MRD in AML

December 3rd 2019

Eytan M. Stein, MD, discusses the importance of measuring for measurable residual disease in acute myeloid leukemia.

Study Results Show Greater Hypertension, Cardiovascular Risks With Ibrutinib

November 29th 2019

Use of ibrutinib (Imbruvica) significantly increased the risk of early onset hypertension and was associated with long-term risk of developing other major cardiotoxic events in patients with B-cell malignancies.

Therapeutics Beyond JAK Inhibitors Needed in Polycythemia Vera and Myelofibrosis

November 27th 2019

Raajit K. Rampal, MD, PhD, discusses current available treatments for patients with polycythemia vera and myelofibrosis, as well as the unmet needs in this area of research.

Fostamatinib Slated for EU Approval in Chronic ITP

November 16th 2019

The European Medicines Agency’s Committee for Medicinal Products for Human Use has issued a positive opinion for a Marketing Authorization Application of fostamatinib disodium hexahydrate for the treatment of adult patients with chronic immune thrombocytopenia who are refractory to other treatments.

EU Panel Backs Polatuzumab Vedotin Approval for DLBCL

November 15th 2019

The European Medicines Agency’s Committee for Medicinal Products for Human Use has recommended approval of the antibody-drug conjugate polatuzumab vedotin for use in combination with bendamustine and rituximab for the treatment of patients with relapsed/refractory diffuse large B-cell lymphoma who are not candidates for a hematopoietic stem cell transplant.

Lenalidomide/Rituximab Combo Nears EU Approval for Follicular Lymphoma

November 15th 2019

The European Medicines Agency’s Committee for Medicinal Products for Human Use has recommended the combination of lenalidomide and rituximab for the treatment of adult patients with grade 1 to 3a previously treated follicular lymphoma.

Rapid Growth of Targeted Therapies in AML Spurs Need for More Learning

November 14th 2019

During a recent OncLive Peer Exchange® program, a panel of leukemia experts provided an overview of these agents and shared their perspectives on how clinicians can incorporate them into their clinical practice.

KD025 Hits High Response Rate in Chronic GVHD

November 12th 2019

Treatment with the selective ROCK2 inhibitor KD025 led to statistically significant overall response rates in patients with chronic graft-versus-host disease who have received ≥2 prior lines of systemic therapy.

Investigators Link Novel Biomarker to Therapy in DLBCL Trial

November 12th 2019

Investigators are exploring the novel genetic biomarker DGM1 as a potential predictor of benefit from the experimental agent enzastaurin in treatment-naïve patients with high-risk diffuse large B-cell lymphoma.

FDA Approves Luspatercept for Beta Thalassemia–Associated Anemia

November 8th 2019

The FDA has approved luspatercept-aamt (Reblozyl) for the treatment of anemia in adult patients with beta thalassemia who require regular red blood cell transfusions.

Ixazomib Improves PFS as Frontline Maintenance in Multiple Myeloma

November 7th 2019

Ixazomib significantly improved progression-free survival as a first-line maintenance therapy compared with placebo in adult patients with multiple myeloma who have not undergone stem cell transplantation, meeting the primary endpoint of the phase III TOURMALINE-MM4 study.

Novel Combinations Could Improve Cure Rates for Adult ALL

November 7th 2019

Novel combinations of biologic therapies, third-generation TKIs, and chemotherapy could lead to significantly higher cure rates for adult patients with acute lymphoblastic leukemia, with a number of early stage studies already showing promising results, according to Hagop M. Kantarjian, MD, at the 37th Annual CFS®.

Expert Explains Treatment Considerations in Newly Diagnosed Follicular Lymphoma

November 7th 2019

Given that a watch-and-wait approach is a viable option, clinicians must carefully consider disease characteristics when selecting a treatment strategy in newly diagnosed follicular lymphoma.

New Sequencing Approaches Shape Follicular Lymphoma Landscape

November 6th 2019

With a variety of available agents in follicular lymphoma, determining which treatments to choose and how best to sequence them can be challenging.

Dr. Zain on Targets Under Investigation in T-Cell Lymphomas

November 6th 2019

Jasmine M. Zain, MD, hematologist/oncologist, associate clinical professor, Hematology and Hematopoietic Cell Transplantation, and director, T cell Lymphoma program, City of Hope, discusses targets that are under investigation in T-cell lymphomas.

NEJM Data Highlight Gilteritinib Survival Benefit in FLT3+ AML

November 1st 2019

Gilteritinib demonstrated a higher remission rate and a statistically significant improvement in overall survival compared with salvage chemotherapy in patients with relapsed/refractory acute myeloid leukemia who harbor a FLT3 mutation.

Experts Provide Insight on Aspects of Cancer Care That Are Not as Widespread in Community Practice

November 1st 2019

OncLive interviewed experts at the State of the Science Summits™ in October 2019 on what they wish more people knew in community practice that is not yet widespread.