HER2+ Breast Cancer | Specialty

Dr. Baselga Discusses Upcoming BOLERO-3 Data

April 18th 2013

José Baselga, MD, PhD, Physician-in-Chief, Memorial Sloan-Kettering Cancer Center, discusses everolimus and the upcoming data from the BOLERO-3 trial in breast cancer.

Dr. Ron Bose on HER2 Gene Mutations in Breast Cancer

March 8th 2013

Ron Bose, MD, PhD, from the Siteman Cancer Center, discusses the prevalence of HER2 gene mutations in patients diagnosed with breast cancer.

HER2 Mutations Identified as Treatment Targets in Patients With HER2-Negative Breast Cancer

February 5th 2013

Patients with breast cancer who do not exhibit amplifications of the HER2 gene may still have mutations of HER2 that drive the progression of their cancer, suggesting that these mutations could serve as therapeutic targets.

Guideline Adherence Is Vital to HER2 Accuracy

January 31st 2013

Efforts to improve guidelines continue for HER2 testing and the evaluation of whether patients' tumors are estrogen receptor-positive and progesterone receptor-positive.

Addition of PI3K Inhibitor May Prevent or Delay Resistance to Therapy in HER2+ Breast Cancer

January 23rd 2013

A new study found that patients with HER2-positive breast cancer who are receiving anti-HER2 therapy could prevent or delay resistance when a phosphatidylinositol-3 kinase (PI3K) inhibitor is added during treatment.

Lapatinib Plus Trastuzumab Bests Lapatinib Monotherapy in HER2-Positive Metastatic Breast Cancer

November 7th 2012

Investigators have documented a significant 4.5-month median overall survival advantage with lapatinib combined with trastuzumab in women with heavily pretreated HER2-positive metastatic breast cancer.

Management of Comorbidities in Early Breast Cancer

October 25th 2012

Novel Strategies for Treatment of Early Breast Cancer, Part II

October 25th 2012

Novel Strategies for Treatment of Early Breast Cancer, Part I

October 25th 2012

Anthracyclines for Early-Stage HER2-Positive Breast Cancer

October 25th 2012

Hormonal and HER2-Targeted Therapy in Early Breast Cancer

October 25th 2012

Dr. Aithal on the HERceptin Adjuvant (HERA) Trial

October 25th 2012

Sramila Aithal, MD, from Cancer Treatment Centers of America, discusses the HERceptin Adjuvant (HERA) trial that examined adjuvant therapy with trastuzumab for women with HER2-positive early breast cancer.

Breast Oncologists Incorporate New Treatments, Grapple With Ongoing Challenges

October 5th 2012

During the 11th International Congress on The Future of Breast Cancer, Hope Rugo, MD, offered a snapshot of the research community's progress in the study and treatment of the disease.

One Year of Adjuvant Trastuzumab Remains Standard of Care

October 3rd 2012

Long-term follow-up of the HERA trial confirms that 1 year of adjuvant therapy with trastuzumab should remain the standard of care for treatment of women with HER2-positive invasive early breast cancer.

Updated Data Show T-DM1 Improves Overall Survival in HER2-Positive Breast Cancer

October 1st 2012

An updated analysis of the phase III EMILIA trial showed that T-DM1 significantly extended survival in women with HER2-positive, unresectable, locally advanced or metastatic breast cancer.

Subcutaneous Trastuzumab May Offer Benefits Over Standard IV Infusion in Patients With Breast Cancer

September 26th 2012

A new formulation of trastuzumab that is administered subcutaneously appears to be as effective as the approved bodyweight-based intravenous regimen in women with HER2-positive breast cancer.

Beyond Tumor Type: HER2 Link in Leukemia Setting Shows Molecular Profiling Potential

September 21st 2012

Trastuzumab has demonstrated activity in patients with B-cell adult acute lymphocytic leukemia who exhibit evidence of upregulation of the HER2 receptor.

Dr. Hammond Discusses HER2 Testing Guideline Revisions

September 20th 2012

Pathologist Dr. Elizabeth Hammond, from Intermountain Healthcare, Discusses the Ongoing ASCO/CAP HER2 Testing Guideline Revisions.

Putting Key Developments in Two Tumor Types in Focus

July 27th 2012

As the molecular understanding of breast cancer continues to evolve, the search for treatment targets based upon tumor subtypes and gene expression patterns is intensifying.

Dr. Baselga on Combining Pertuzumab with Trastuzumab

June 8th 2012

Dr. José Baselga, from Massachusetts General Hospital, on combining pertuzumab with trastuzumab