Lung Cancer | Specialty

Data Updates From the GioTag Study

September 29th 2020

The Use of TKIs in Patients With Brain Metastases

September 29th 2020

Approved Frontline TKIs for EGFR-Mutated Disease

September 29th 2020

Molecular Testing Prior to Metastases

September 29th 2020

Metastatic NSCLC: The Role of Liquid Biopsy

September 29th 2020

Molecular Testing in Metastatic NSCLC

September 29th 2020

Dr. Levy on the Role of Dabrafenib/Trametinib in BRAF V600E-Mutant NSCLC

September 28th 2020

Benjamin P. Levy, MD, discusses the role of the combination of dabrafenib and trametinib in BRAF V600E-mutant non–small cell lung cancer.

Dissecting the Data With Immune-Based Combinations in Advanced Nonsquamous NSCLC

September 28th 2020

Jonathan Dowell, MD, discusses the data that support the use of chemoimmunotherapy in the frontline setting of nonsquamous NSCLC.

Leveraging Immunotherapy and Targeted Therapy for Cure in Lung Cancer

September 26th 2020

Efforts to leverage targeted therapy and immunotherapy, which have been approved modalities in advanced non–small cell lung cancer, are leading to improved survival in patients with advanced and earlier-stage disease.

Dr. Levy on the DFS Benefit Achieved With Adjuvant Osimertinib in EGFR+ NSCLC

September 25th 2020

Benjamin P. Levy, MD, discusses the disease-free survival benefit with adjuvant osimertinib in the phase 3 ADAURA trial.

FDA Approval Insights: Lurbinectedin in Metastatic SCLC

September 24th 2020

In our exclusive interview, Jacob Sands, MD, discusses the FDA approval of lurbinectedin in small cell lung cancer and shed light on key findings from the phase 2 basket trial that served as the basis for the approval.

Experts Call for Increased Awareness of Existing Racial Disparities in RCC, Other Malignancies

September 24th 2020

Despite the numerous reports detailing racial differences in cancer outcomes and care over the years, the reasons underlying these disparities continue to be under deep exploration.

Cemiplimab Demonstrates Frontline Potential in Advanced PD-L1+ NSCLC

September 21st 2020

Cemiplimab-rwlc monotherapy led to a significant improvement in overall survival and progression-free survival versus platinum-doublet chemotherapy as first-line therapy in patients with advanced non–small cell lung cancer with PD-L1 expression on at least 50% of their tumor cell.

Durvalumab/Tremelimumab Shows Modest Activity in Advanced NETs With GEP and Lung Origins

September 21st 2020

The addition of durvalumab to tremelimumab showed modest activity in patients with advanced neuroendocrine tumors of gastroenteropancreatic and lung origins.

Osimertinib Improves CNS Disease-Free Survival in Early EGFRm NSCLC

September 21st 2020

Osimertinib reduced the risk for central nervous system death or progression by 82% in patients with early-stage EGFR mutated non–small cell lung cancer following complete tumor resection.

BLU-945 Elicits Robust Clinical Activity in Preclinical EGFR+ Lung Cancer Models

September 20th 2020

BLU-945, an investigational precision therapy, elicited robust antitumor activity in multiple preclinical models of triple-mutated EGFR-positive non–small cell lung cancer .

EGFR-MET Bispecific Antibody Amivantamab Excels in Advanced EGFR-Mutant NSCLC

September 20th 2020

The combination of amivantamab and lazertinib demonstrated high response rates and was well tolerated in treatment-naïve and osimertinib-resistant patients with advanced EGFR-mutant non–small cell lung cancer.

First-Line Apatinib/Gefitinib Combo Shows Significant Benefit for EGFR-Mutant NSCLC

September 20th 2020

Dual inhibition of both VEGFR and EGFR with the combination of apatinib and gefitinib in the first-line treatment of patients with advanced EGFR-mutant non–small cell lung cancer demonstrated superior progression-free survival.

Osimertinib/Bevacizumab Combination Fails to Prolong PFS in EGFR T790M+ Lung Cancer

September 20th 2020

The combination of osimertinib and bevacizumab did not prolong progression-free survival in patients with advanced adenocarcinoma who had EGFR T790M mutations compared with osimertinib alone

Sotorasib Shows Encouraging Antitumor Activity in Advanced NSCLC

September 20th 2020

The investigational drug sotorasib demonstrated promising antitumor activity in patients with non-small cell lung cancer that harbor the KRAS p.G12C mutation, an aberration for which no targeted treatment has yet been approved.