Lung Cancer | Specialty

The OncLive Lung Cancer condition center page is a comprehensive resource for clinical news and expert insights on non–small cell lung cancer, small cell lung cancer, mesothelioma, and more. This page features news articles, interviews in written and video format, and podcasts that focus on unmet needs, treatment advances, and ongoing research in lung cancer.

Dr. Raez on the Potential Utility of Cemiplimab in NSCLC

February 8th 2021

Luis E. Raez, MD, discusses the potential utility of cemiplimab-rwlc in non–small cell lung cancer.

Strategizing Effective Ways to Overcome TKI Resistance in ALK+ NSCLC

February 8th 2021

Vincent Lam, MD, describes frontline indications for this patient population, as well as strategies that can be utilized to overcome TKI resistance in later lines of therapy.

Forde Recaps Chemoimmunotherapy Activity in PD-L1–Negative NSCLC

February 8th 2021

Immunotherapy plus chemotherapy is a standard of care for patients with advanced PD-L1–negative non–small cell lung cancer who do not harbor actionable driver mutations.

Future of Frontline EGFR+ NSCLC Features TKI, Chemo Combos and Improved Molecular Profiling

February 7th 2021

Synergizing EGFR TKIs with antiangiogenic agents and chemotherapy, as well as improving the use of molecular classification, are novel strategies aimed at taking the frontline setting for patients with EGFR-mutant non–small cell lung cancer to the next level.

Durvalumab Delivers Durable Benefit, Regardless of PD-L1 Expression, in NSCLC

February 7th 2021

Mark A. Socinski, MD, discusses the nuances of the PACIFIC trial and ongoing research with durvalumab that could extend the reach of immunotherapy in early-stage lung cancer.

ADAURA Raises Questions About Optimal Use of Adjuvant EGFR TKIs in NSCLC

February 6th 2021

Over the past 2 decades, the field of EGFR-mutated non–small cell lung cancer has grown tremendously, but the influx of data and the recent regulatory approval of adjuvant osimertinib have raised several important questions to be addressed to ensure that the optimal treatment approach is utilized.

Lung Cancer Paradigm Pushes Toward Accessible Care and Improved Telemedicine

February 6th 2021

Rogerio C. Lilenbaum, MD, discusses some of the key clinical issues facing the lung cancer field, the role of genomic testing and multidisciplinary care, and the challenges that arose with telemedicine during the coronavirus disease 2019 pandemic.

Experts Take Stock of Critical Clinical Issues in Lung Cancer

February 6th 2021

In the quest for scientific purity, one should not lose sight of the meaningful end points that can make a difference in patients’ daily lives.

Dr. Fidler on the Potential Utility of ctDNA to Inform Treatment Escalation in Lung Cancer

February 6th 2021

Mary Jo J. Fidler, MD, discusses the potential utility of circulating tumor DNA to inform treatment escalation in lung cancer.

Dr. Lilenbaum on the Challenges of Integrating Telehealth Services in Lung Cancer

February 6th 2021

Rogerio C. Lilenbaum, MD, discusses the challenges of integrating telehealth services in lung cancer.

Dr. Socinski on the Role of Immunotherapy in PD-L1–Negative Lung Cancer

February 6th 2021

Mark A. Socinski, MD, discusses the role of immunotherapy in PD-L1–negative lung cancer.

Dr. Borghaei on Selecting Single-Agent Versus Combination Therapy in Lung Cancer

February 6th 2021

Hossein Borghaei, DO, MS, discusses selecting between single-agent versus combination therapies in lung cancer.

Systemic Treatment Options Expand in Nonmetastatic NSCLC

February 5th 2021

Although advances in diagnosis and treatment have led to improvements in overall survival for patients with NSCLC, low rates of survival outcomes are present even in those with nonmetastatic disease.

Pralsetinib Approval Expands Options for RET-Positive Thyroid Cancers

February 5th 2021

Lori J. Wirth, MD, , discusses the potential impact of pralsetinib on the thyroid cancer treatment landscape.

Surgery Stakes Claim in Lung Cancer Despite Evolution of Systemic Therapy

February 5th 2021

Surgical resection should be a standard of care for patients with stage I to IIIA lung cancer, but probing for subclinical stage III disease with endobronchial ultrasound guided biopsy or mediastinoscopy to determine whether surgery should be performed prior to or after systemic therapy.

Hanhan Highlights How Robotic Techniques Have Shifted Surgical Care in Lung Cancer

February 4th 2021

Ziad Hanhan MD, MPH, FACS, highlights the evolution of surgery in the field of lung cancer, the advantages associated with robotic techniques, and the crucial role of the surgeon in determining eligibility for these approaches.

2020 Approvals Expand Access to Care for Patients Across Tumor Types

February 4th 2021

In a year marked by collaboration and innovation, therapeutic developments in oncology care once again dominated the novel drug approvals in 2020.

Low-Dose Chest CT Reduces Lung Cancer Mortality, but Barriers Remain

February 3rd 2021

Florian Fintelmann, MD, discusses lung cancer screening with low-dose chest CT, barriers to testing, and the potential expansion of USPSTF lung cancer screening guidelines.

FDA Approves Tepotinib for METex14-Altered Metastatic NSCLC

February 3rd 2021

February 3, 2021- The FDA has granted an accelerated approval to tepotinib for adult patients with metastatic non–small cell lung cancer harboring MET exon 14 skipping alterations.

Ceralasertib/Durvalumab Combo Shows Efficacy in NSCLC Following Anti–PD-L1 Therapy

February 3rd 2021

February 3, 2021 - The combination of ceralasertib plus durvalumab improved overall response rate in patients with non‒small cell lung cancer who progressed on an anti-PD-1/PD-L1 therapy.