A Multidisciplinary Approach to CAR T-cell Therapy for Adult Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia

EP. 1: CAR T-cell Therapy for B-ALL

December 24th 2024

A panelist discusses how CAR-T cell therapy patient selection involves evaluating disease characteristics like relapse/refractory status and tumor burden, patient-specific factors including performance status and organ function, with extramedullary disease requiring careful monitoring while isolated CNS disease may warrant alternative treatments or clinical trials.

EP. 2: Navigating Treatment Selections for B-ALL: Insights From the Moffitt Cancer Center

March 7th 2025

Experts discuss the key factors influencing product selection in treatment choices at their center, emphasizing clinical efficacy, patient safety, cost-effectiveness, and personalized care.

EP. 3: The Multidisciplinary Approach to CAR T-Cell Therapy for B-ALL

March 7th 2025

Experts discuss the composition of their multidisciplinary hematologic oncology team, highlighting collaboration among hematologists, oncologists, nurses, pathologists, and other specialists to provide comprehensive patient care.

EP. 4: CAR T-Cell Therapy for B-ALL: Roles Within the Multidisciplinary Care Team

March 14th 2025

Experts discuss their distinct roles in patient eligibility, management, and follow-up for chimeric antigen receptor (CAR) T-cell therapy treatment in adult patients with precursor B-cell acute lymphoblastic leukemia (B-ALL), focusing on assessment, treatment planning, and ongoing care.

EP. 5: Optimizing Molecular Profiling for B-ALL Treatment

March 14th 2025

Experts discuss the timing and process of obtaining molecular profiles for genetic variants and T-cell biomarkers during patient assessment, including the team member responsible for ordering the test and whether Moffitt Cancer Center uses a preferred assay for adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL).

EP. 6: Multidisciplinary Clinical Perspectives: Factors That Influence CAR T-Cell Sequencing in B-ALL

March 21st 2025

Experts discuss the chimeric antigen receptor (CAR) T-cell treatment paradigm at Moffitt Cancer Center, exploring how treatment sequencing differs for Philadelphia chromosome–positive vs –negative acute lymphoblastic leukemia (ALL), varying risk factors, extramedullary disease, disease bulk, and bone marrow blast percentage, as well as how prior therapies such as blinatumomab and inotuzumab affect treatment selection for adult patients with CD19-positive or CD22-positive relapsed or refractory disease and the influence of clinical trial data on patient care.

EP. 7: Considerations Regarding Bridging Therapy for B-ALL CAR T-Cell Treatment

March 21st 2025

Experts discuss the routine initiation of bridging therapy between leukapheresis and chimeric antigen receptor (CAR) T-cell infusion at their center; the pharmacist’s role in implementing this procedure; collaboration with the team on agent choice, dosage, and administration; and monitoring for disease control and adverse events as well as the observed impact of bridging therapy on outcomes post CAR T-cell therapy.

EP. 8: Obe-Cel for B-ALL: Insights Regarding Persistence, Toxicity, and Remission

March 28th 2025

Experts discuss the steps taken to ensure optimal T-cell persistence with chimeric antigen receptor (CAR) T-cell therapy, exploring the underlying mechanisms of toxicity and T-cell exhaustion and the advantages of fast off-rate kinetics, defining durable remission post CAR T-cell therapy, and sharing their views on the benefits and risks of approved CAR T-cell therapies for adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL).

EP. 9: CAR T-Cell Therapy Decisions in B-ALL: The Role of Obe-Cel in B-ALL Treatment

March 28th 2025

Experts discuss how the safety profiles of various chimeric antigen receptor (CAR) T-cell therapies influence final selection, considering other patient and disease factors that may affect the decision and how the multidisciplinary team communicates on procedural issues, clinical decisions, responsible parties, and next steps in the CAR T-cell therapy process, as well as the routine adoption of tumor burden–guided dosing following patient reevaluation and lymphodepletion.

EP. 10: Managing Immunotoxicities With CAR T-Cell Therapy for B-ALL

April 4th 2025

Experts discuss their combined experience with cytokine release syndrome (CRS), immune effector cell–associated neurotoxicity syndrome (ICANS), and other immunotoxicities post chimeric antigen receptor (CAR) T-cell therapy, whether Moffitt Cancer Center implements a standardized protocol to address and resolve cell therapy–associated immunotoxicities, how interventions are modified across grades of severity, and the use of prophylactic strategies to mitigate treatment-related adverse events as well as the roles of the multidisciplinary team in patient monitoring during the initial 30 days and the longer-term postinfusion period.