Recent Advances in the Treatment of Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma

A distinguished panel of experts in hematologic malignancies builds a lively discussion on recent clinical trials and potential advancements in the treatment of mantle cell lymphoma and chronic lymphocytic leukemia.

EP. 1: Disease Overview: Mantle Cell Lymphoma

July 15th 2022

Anthony R. Mato, MD, MSCE, introduces the panel, and Alexey V. Danilov, MD, PhD, provides an overview of the incidence, presentation, pathologic features, and treatment landscape for mantle cell lymphoma.

EP. 2: Factors for Consideration in Treatment Decision-making for MCL

July 15th 2022

Focusing on the differences in treatment considerations between younger and older patients, Michael Wang, MD, discusses the current treatment landscape in mantle cell lymphoma.

EP. 3: Mantle Cell Lymphoma Maintenance Strategies

July 22nd 2022

A panel of experts in hematologic malignancies discusses maintenance strategies for mantle cell lymphoma with particular emphasis on treatment considerations related to the COVID-19 pandemic and real-world data.

EP. 4: Second-line Therapies in MCL: Regimens With BTK Inhibitors and BCL-2 Targeting Therapies

July 22nd 2022

Key opinion leaders in mantle cell lymphoma discuss the emergence of more effective novel therapies such as BTK inhibitors and BCL-2 inhibitors and whether there is a continued role for lenalidomide-based regimens.

EP. 5: BTK Inhibitors in Relapsed/Refractory MCL and Treatment Selection

July 29th 2022

Panelists discuss treatment considerations in the use of BTK inhibitors for relapsed/refractory mantle cell lymphoma, with Matthew S. Davids, MD, MMSc, reviewing strategies for the management of AEs.

EP. 6: CAR T-Cell Therapy in R/R MCL

July 29th 2022

Michael Wang, MD, guides the panel in a discussion on CAR T-cell therapy for relapsed/refractory MCL including a summary of key takeaways from the ZUMA-2 trial and a conversation on real-world vs clinical trial data.

EP. 7: Strategies for Sequencing and Combining Therapies in MCL

August 5th 2022

A panel of distinguished faculty builds a lively conversation on the emergence of pirtobrutinib and its effect on treatment sequencing strategies in MCL as well as the overall role of doublet and triplet regimens.

EP. 8: Advancements on the Horizon in Mantle Cell Lymphoma

August 5th 2022

Thought leaders in hematologic malignancies reflect on studies of ROR1 and share perspectives on advancements on the horizon for mantle cell lymphoma.

EP. 9: Treatment Overview: Chronic Lymphocytic Leukemia

August 12th 2022

Catherine C. Coombs, MD, leads the faculty in a discussion of the current treatment landscape for CLL with a review of considerations for patients with high-risk or relapsed/refractory disease.

EP. 10: Acalabrutinib in CLL: Insights from the ELEVATE TN and ASCEND Trials

August 12th 2022

Highlighting the ELEVATE TN and ASCEND clinical trials, panelists share expert insights into the next-generation BTK inhibitor acalabrutinib for CLL.

EP. 11: Zanubrutinib in CLL: The ALPINE Trial

August 19th 2022

An expert in hematologic malignancies, Catherine C. Coombs, MD, shares insights gleaned from the ALPINE clinical trial of zanubrutinib vs ibrutinib for relapsed/refractory CLL.

EP. 12: Treatment Decision-making Among Second-generation BTKis in CLL

August 19th 2022

Key opinion leaders in CLL review factors driving therapeutic decision-making among the available second-generation BTK inhibitors including efficacy and safety considerations.

EP. 13: Updates from Patient-reported QOL and Matching-adjusted Indirect Treatment Comparisons (MAICs) Studies in CLL

August 26th 2022

Brian T. Hill, MD, PhD, and Matthew S. Davids, MD, MMSc, address the role of study design in CLL to highlight the importance of patient-reported QOL outcomes and matching-adjusted indirect treatment comparisons (MAICs).

EP. 14: Emerging Approaches in CLL

August 26th 2022

The faculty members share expert insights into treatment approaches for patients with double-refractory chronic lymphocytic leukemia.

EP. 15: TRANSCEND CLL: CAR T-cell Therapy for CLL

September 2nd 2022

Panelists respond to a question from Michael Wang, MD, about the role of CAR T-cell therapy in CLL, and Brian T. Hill, MD, PhD, summarizes takeaways from the TRANSCEND CLL study.

EP. 16: The Potential Role of Venetoclax Combination Approaches in CLL

September 2nd 2022

Experts in hematologic malignancies reflect on clinical trials studying venetoclax combination approaches including the CAPTIVATE, FLAIR, GLOW, VISION, SEQUOIA, and MAJIC studies.

EP. 17: Considerations for COVID-19 in MCL and CLL

September 9th 2022

Focusing the discussion on the current state of the COVID-19 pandemic, Catherine C. Coombs, MD, shares key insights into the use of COVID-19 pre-exposure prevention for patients with CLL or MCL.

EP. 18: Anti-CD20 Regimens and Triplet Therapies in CLL

September 9th 2022

Orienting the conversation around anti-CD20-drug-based combination and sequencing approaches, the panelists examine key takeaways from the CLL13 and CLL14 clinical trials as well as expectations for real-world data in the future.

EP. 19: Pirtobrutinib and Other Non-Covalent BTK Inhibitors in the Treatment of CLL

September 15th 2022

The assembled faculty comment on data on the role of non-covalent BTK inhibitors in the CLL treatment landscape, with emphasis on the phase 1/2 BRUIN trial of pirtobrutinib.

EP. 20: Closing Remarks on Upcoming Data and Future Perspectives in MCL and CLL

September 15th 2022

Looking to the future, a panel of experts offers closing remarks on research in CLL and MCL including hopes for further data on bispecific antibodies, BTK degraders, CAR T-cell therapy, and pirtobrutinib.