Updates in HER2+ Early and Metastatic Breast Cancer

A panel of experts summarizes the current HR+ breast cancer treatment landscape and discusses recent data updates in the field, including those presented at the 2022 San Antonio Breast Cancer Symposium (SABCS).

EP. 1: Incidence and Typical Prognosis of HER2+ Early Breast Cancer

January 20th 2023

Virginia Borges, MD, explains how common HER2+ early breast cancer is and the goals of treatment for patients.

EP. 2: Neoadjuvant Treatment of HER2+ Early Breast Cancer

January 20th 2023

A review of the standard of care regimens for the preoperative or neoadjuvant treatment of HER2+ early breast cancer.

EP. 3: De-Escalation Approaches in Patients with HER2+ Early Breast Cancer

January 30th 2023

Debu Tripathy, MD, details when he utilizes a treatment de-escalation approach in his patients with HER2+ early breast cancer.

EP. 4: Subcutaneous vs Intravenous Pertuzumab/Trastuzumab for Treatment of HER2+ Early Breast Cancer

January 30th 2023

The panel shares the factors that influence whether they recommend a subcutaneous or intravenous formulation of pertuzumab/trastuzumab in addition to chemotherapy.

EP. 5: Factors Informing Adjuvant Treatment Selection in HER2+ Early Breast Cancer

February 7th 2023

A look at how patient response to neoadjuvant treatment for HER2+ early breast cancer informs adjuvant treatment selection.

EP. 6: Expert Perspectives on Clinical Experience with Ado-Trastuzumab Emtansine (T-DM1)

February 7th 2023

The panel explains their clinical experiences with using the antibody-drug conjugate (ADC) ado-trastuzumab emtansine (T-DM1) to treat HER2+ early breast cancer.

EP. 7: Clinical Data Updates on Adjuvant Pertuzumab/Trastuzumab for HER2+ Early Breast Cancer

February 13th 2023

A review of recently reported data on the use of adjuvant pertuzumab/trastuzumab for the treatment of HER2+ early breast cancer, including data from the APHINITY and PHranceSCa trials.

EP. 8: Extended Adjuvant Neratinib Therapy for Patients with HER2+ Early Breast Cancer

February 13th 2023

Joyce O’Shaughnessy, MD, starts a conversation on which patients with HER2+ early breast cancer are the best candidates for extended adjuvant neratinib therapy.

EP. 9: Data Updates in Adjuvant HER2+ Early Breast Cancer from SABCS 2022

February 21st 2023

The panel highlights recent data updates in adjuvant treatment of HER2+ early breast cancer, including longer-term follow-up data from the APT and ATEMPT trials.

EP. 10: HER2+ mBC: First-Line Treatment Regimens

February 21st 2023

A focused discussion on available options for the first-line treatment of HER2+ metastatic breast cancer (mBC), with reference to data from the CLEOPATRA trial.

EP. 11: Second-Line Treatment of HER2+ mBC and Recent Data Updates

February 27th 2023

Maryam Lustberg, MD, MPH introduces the standard of care regimens for the second-line treatment of HER2+ metastatic breast cancer, followed by a discussion of recent data on the ADC trastuzumab deruxtecan (T-DXd).

EP. 12: Options for Third- and Further-Line Treatment of HER2+ mBC

February 27th 2023

Dr Debu Tripathy explains the treatment options for patients with HER2+ metastatic breast cancer in the third-line and later-line settings, including combination tucatinib/trastuzumab/capecitabine.

EP. 13: Use of MRI for Surveillance of Brain Metastases in Patients with HER2+ mBC

March 6th 2023

The panel discusses the management of patients with HER2+ mBC with asymptomatic brain mets and shares their thoughts on the use of surveillance brain MRI in this setting.

EP. 14: Emerging Data and Investigational Agents in HER2+ mBC

March 6th 2023

The panel highlights emerging data from SABCS 2022 on investigational agents being explored for HER2+ mBC treatment.

EP. 15: Unmet Needs and the Future of HER2+ Breast Cancer Treatment

March 6th 2023

The panel closes their discussion by summarizing the most exciting recent advances in HER2+ breast cancer, the future of treatment, and unmet needs that must be addressed.