AR Pathway Inhibition Refines Prostate Cancer Treatment Strategies: With Neal Shore, MD, FACS

Welcome to OncLive On Air®! I’m your host today, Ashling Wahner.

OncLive On Air is a podcast from OncLive®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, supported by Johnson & Johnson, we had the pleasure of speaking with Neal Shore, MD, FACS, about prostate cancer management and the use of androgen receptor (AR)–directed therapies. Dr Shore is the medical director for the Carolina Urologic Research Center in Myrtle Beach, South Carolina.

In our exclusive interview, we sat down with Dr Shore during the 2025 Bridging the Gaps in Prostate Cancer meeting to discuss the importance of multidisciplinary meetings to address unmet needs for patients with prostate cancer, the need for treatment strategies that improve upon the activity of current standards of care in this disease, the evolving roles of neoadjuvant and adjuvant therapies, and the significance of biomarkers and imaging. He also highlighted treatment advances that have been achieved with AR-directed agents, such as apalutamide (Erleada) and darolutamide (Nubeqa), along with considerations for the optimal intensification and de-intensification of these agents to balance efficacy and quality of life.

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That’s all we have for today! Thank you for listening to this episode of OncLive On Air, supported by Johnson & Johnson. Check back on Mondays and Thursdays for exclusive interviews with leading experts in the oncology field.

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