Emmanuel S. Antonarakis, MBBCh, assistant professor, Johns Hopkins Medicine, discusses a study looking at androgen receptor splice variant 7 (AR-V7) in metastatic castration-resistant prostate cancer (mCRPC).

In a previous study, it was seen that the presence of AR-V7 was associated with little or no response to the agents abiraterone and enzalutamide.

In this analysis, researchers looked at the correlation of the presence of AR-V7 and response to taxane chemotherapies. Antonarakis says that AR-V7 did not cause primary resistance to taxane chemotherapies. If a patient is diagnosed with AR-V7 in their tumors, they may not respond to abiraterone or enzalutamide, but he has a decent chance of responding to chemotherapy.

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The OncLive Prostate Cancer condition center page is a comprehensive resource for clinical news and expert insights on how to approach treatment for patients with nonmetastatic, castration-resistant, or castration-sensitive prostate cancer. This page features news articles, interviews in written and video format, and podcasts that focus on unmet needs, ongoing research, and treatment advances with androgen receptor inhibitors, PARP inhibitors, and more in prostate cancer.

Dr. Emmanuel Antonarakis on AR-V7 and Response to Taxanes in mCRPC