Dr. Atkinson Discusses the COLUMBUS Trial for Melanoma

Victoria Atkinson, MD, medical oncologist, Princess Alexandra Hospital, University of Queensland, discusses the COLUMBUS trial for patients with melanoma.

The COLUMBUS trial investigates the combination of encorafenib and binimetinib. Patients who received encorafenib and binimetinib experienced less photosensitivity and rash, which has been seen with the vemurafenib (Zelboraf) and cobimetinib (Cotellic) compounds, states Atkinson.

The COLUMBUS data are unique since it uses the highest dose of a BRAF inhibitor. This is done in the hopes to have the maximum blockade of the MAP-kinase pathway, explains Atkinson. This trial has seen the longest progression-free survival of targeted therapies.

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