Dr. Bradley on the Background of the RTOG 0617 Study

Jeffrey D. Bradley, MD, Professor, Radiation Oncology, Washington University School of Medicine in St. Louis, discusses the background of the phase III RTOG 0617 study.

In the phase III randomized trial, patients with stage III non-small cell lung cancer were randomized to high-dose (74 Gy) or standard-dose (60 Gy) chemoradiotherapy with or without cetuximab. Patients were divided into four arms in a 2x2 factorial design.

The second randomization in this trial was for patients to be given cetuximab during and after radiation therapy. At the 2013 American Society of Clinical Oncology Meeting, Bradley presented on the first randomization -- the radiation dose question.

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