Dr. Choueiri on Savolitinib in Papillary Renal Cell Cancer

Toni Choueiri, MD, clinical director, Lank Center for Genitourinary Oncology, director, Kidney Cancer Center, senior physician, Dana-Farber Cancer Institute, discusses savolitinib in papillary renal cell cancer (PRCC).

In the largest PRCC trial to date, savolitinib, a specific MET-only inhbitor, was evaluated in this patient population. Although little is known about the biology of PRCC, says Choueiri, a subset of patients harbor an alteration in the MET gene—MET mutation, MET amplificiation, and others.

Savolitinib was generally well tolerated in MET-driven patients, but further clinical investigation is warrented, says Choueiri.