Dr. Cortes on BP-100.01 in Patients With Relapsed/Refractory AML

Jorge E. Cortes, MD, deputy department chair, professor of Medicine and Internist, chair, AML Sections, D. B. Lane Cancer Research Distinguished Professor for Leukemia Research, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, discusses the mechanism of action for BP-100.01.

BP-100.01 is an oligonucleotide liposome-incorporated antisense that is targeted against growth receptor bound protein-2 (GRB-2), Cortes explains. GRB-2 is a component that transmits the signal of certain kinases such as BCR-ABL to downstream receptors, such as MEK. By blocking this signal, delivery will be prevented.

This agent could be beneficial in patients with both acute myeloid leukemia and chronic myeloid leukemia, Cortes adds.