Dr. Eskelund on Outcomes of TP53-Mutated MCL

Christian Winther Eskelund, MD, Copenhagen University Hospital, Rigshospitalet, discusses outcomes for patients with TP53-mutated mantle cell lymphoma (MCL).

The significant findings of a study investigating TP53 mutations were that patients who had TP53 mutations did far worse than patients who had no mutations, states Eskelund. The median overall survival was 1.8 years versus 12 years for non-mutated patients.

TP53 is normally associated with poor outcomes in hematologic malignancies, making this an expected outcome, according to Eskelund.