Dr. Jeffrey Jones on Idelalisib Combinations in CLL

Jeffrey Jones, MD, MPH, Assistant Professor of Internal Medicine and section head of the Chronic Lymphocytic Leukemia (CLL) research program at Ohio State University, discusses idelalisib (Zydelig) combinations in CLL.

Although idealisib has been proven effective as a single-agent therapy, sustained remissions that eventually lead to the discontinuation of therapy may require combination therapies, says Jones.

Idealisib has been studied in combination with monoclonal antibodies, chemotherapy, and most recently novel targeted therapies like ofatumumab (Arzerra). Ofatumumab was shown to improve progression-free survival by 8 months in combination with idealisib compared to ofatumumab alone in a phase III randomized, controlled study.