Dr. Klopp Discusses Chemoradiation in Endometrial Cancer

Ann H. Klopp, MD, PhD, an associate professor of radiation oncology at The University of Texas MD Anderson Cancer Center, discusses chemoradiation in endometrial cancer.

Klopp says that the combination of chemotherapy and radiation is the best treatment for patients with stage III endometrial cancer. A trial comparing radiation to chemoradiation showed improved disease-free survival in patients who received chemoradiation. Chemoradiation also reduces the risk of recurrence in the pelvis, which is attributed to the radiation component of the therapy, says Klopp.

In a study comparing chemotherapy with chemoradiation, survival was equivalent, but there was a higher rate of pelvic relapse with chemotherapy alone. This is a symptomatic problem for patients and affects their quality of life, says Klopp.