Ching-Hon Pui, MD, chair, Oncology Department, St. Jude Children's Research Hospital, discusses the use of CAR T-cell therapy in patients with relapsed/refractory acute lymphocytic leukemia (ALL).

CAR T-cell therapy is currently used in pediatric patients with relapsed/refractory ALL. Increasingly, it is used to treat patients with central nervous system relapsed or testicular relapse, says Pui.

In the past, pediatric patients with ALL required radiation to be cured; however, now CAR T-cell therapy can cure those patients without the use of radiation. Pui believes that in the near future, CAR T-cell therapy will be used to treat patients with high-risk ALL and avoid intensive chemotherapy altogether, improving the patient's quality of life as well as the cure rate.

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CAR T-cell Therapy

 CAR T-cell therapy condition center page is a comprehensive resource for clinical news and expert insights on FDA-approved and investigational CAR T-cell products in hematologic malignancies, specifically acute lymphoblastic leukemia, non-Hodgkin lymphoma, and multiple myeloma. CAR T-cell research in solid tumors is also under exploration. This page features news articles, interviews in written and video format, and podcasts that focus on updates with CAR T-cell therapy and the ongoing research with this type of treatment. 

Society of Hematologic Oncology Annual Meeting (SOHO)

Ching-Hon Pui, MD, discusses the use of CAR T-cell therapy in patients with relapsed/refractory acute lymphocytic leukemia.

Dr. Pui on Utilizing CAR T-Cell Therapy in Pediatric ALL