Dr. Ramalingam on the Role of Osimertinib in EGFR T790M-Positive Advanced NSCLC

Suresh S. Ramalingam, MD, professor, Department of Hematology and Medical Oncology, Deputy Director, Winship Cancer Institute of Emory University, discusses the role of osimertinib (Tagrisso) in the treatment of patients with EGFR T790M-positive advanced non-small cell lung cancer (NSCLC), during an interview at the IASLC 17th World Conference on Lung Cancer in Vienna, Austria.

Osimertinib is a potent, irreversible, CNS active, EGFR TKI selective for sensitizing and T790M resistance mutations. The agent is currently indicated for the treatment of patients with locally advanced or metastatic EGFR T790M-positive NSCLC.

In the randomized AURA3 trial, patients who received osimertinib achieved a median progression-free survival of 10.1 months (95% CI, 8.3-12.3) compared with 4.4 months (95% CI, 4.2-5.6) for those treated with platinum chemotherapy plus pemetrexed (HR, 0.30; P <.001).

Osimertinib demonstrated a superior and clinically meaningful efficacy over platinum-pemetrexed in patients with EGFR T790M-positive advanced NSCLC, yielding a 70% reduction in the risk of disease progression and a favorable safety profile.

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