Dr. Secord on the Role of PARP Inhibitors in Ovarian Cancer

Angeles Alvarez Secord, MD, gynecologic oncologist, Duke Cancer Center, discusses the role of PARP inhibitors in ovarian cancer based on their current indications in the treatment landscape.

The role of PARP inhibitors is quite expansive, Secord says. There are indications for PARP inhibitors in the frontline setting with BRCA1/2 somatic or germline mutations, as well as in all-comers with platinum-sensitive disease, regardless of biomarker status.

Each of the PARP inhibitors available have specific indications as well. For example, rucaparib (Rubraca) is indicated for the treatment of patients with BRCA1/2-mutant ovarian cancer, Secords says.

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