Dr Shah on Remaining Unmet Needs in RCC After Frontline IO Combinations

Neil J. Shah, MBBS, discusses unmet needs for patients with RCC receiving immune-oncology–based combinations in the frontline setting.

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    Neil J. Shah, MBBS, assistant attending physician, genitourinary oncologist, Memorial Sloan Kettering Cancer Center, discusses unmet needs for patients with renal cell carcinoma (RCC) receiving immune-oncology (IO)–based combinations in the frontline setting.

    Most patients with advanced RCC will receive an IO/IO or IO/TKI combination in the frontline setting, but unmet needs remain for these patients. Shah and coauthors presented a real-world study during 2024 Kidney Cancer Research Summit, which demonstrated that patients with RCC who received various IO/IO and IO/TKI combinations all experienced similar outcomes, and there is limited overall survival in the post-IO/IO and -IO/TKI setting, underscoring the need for the development of more novel therapies in the space.


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