Dr. Weber on CheckMate-238 for Melanoma

Jeffrey S. Weber, MD, PhD, deputy director and co-director of the Melanoma Program at the Laura and Isaac Perlmutter Cancer Center at NYU Langone Medical Center, discusses the CheckMate-238 trial for patients with melanoma.

CheckMate-238 is a large, randomized, phase III trial investigating nivolumab (Opdivo) versus ipilimumab (Yervoy) in patients with resected stage IIIb, IIIc, and IV melanoma, all of whom were at high risk of relapse, explains Weber.

There was a statistically significant and clinically impressive difference in relapse-free survival in favor of nivolumab compared with ipilimumab at an interim analysis, states Weber. Additionally, there was less toxicity reported in patients receiving nivolumab.