Dr. Wei on Trial of Venetoclax Plus Chemotherapy in AML

Andrew Wei, MBBS, PhD, clinical hematologist, head of Leukemia Research Group, Alfred Hospital, discusses venetoclax (Venclexta) plus chemotherapy in advanced myeloid leukemia (AML).

A phase I trial was conducted to answer the question of whether targeting BCL-2 would be effective in AML.

Venetoclax was combined with low-dose chemotherapy to see whether the combination would raise response rates in relapsed/refractory patients. The combination was very well tolerated, with few severe side effects being reported.