Matthew S. Davids, MD, MMSc, associate director, Center for Chronic Lymphocytic Leukemia, Dana-Farber Cancer Institute, discusses the combination of ibrutinib (Imbruvica) and obinutuzumab (Gazyva) for patients with relapsed or refractory chronic lymphocytic leukemia (CLL).

For patients with relapsed/refractory CLL, ibrutinib is the current standard therapy. There are many combination studies investigating ibrutinib plus obinutuzumab, explains Davids. In a phase Ib study, investigators are determining if the order of administration of ibrutinib and obinutuzumab affects the safety and the efficacy of the combination.

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Matthew S. Davids, MD, MMSc, associate director, Dana-Farber Cancer Institute, Center for Chronic Lymphocytic Leukemia, discusses the combination of ibrutinib (Imbruvica) and obinutuzumab (Gazyva) for patients with relapsed or refractory chronic lymphocytic leukemia (CLL).

Dr. Davids on the Combination of Ibrutinib and Obinutuzumab in CLL

Matthew S. Davids, MD, MMSc, associate director, Dana-Farber Cancer Institute, Center for Chronic Lymphocytic Leukemia, discusses ibrutinib (Imbruiva) plus fludarabine-cyclophosphamide-rituximab (FCR) in younger patients with chronic lymphocytic leukemia (CLL).

In a study of patients aged 65 or less, ibrutinib is being combined with FCR for up to 6 months, followed by ibrutinib maintenance therapy.

Davids says that many patients in this population like the idea of a combinatorial time-limited approach to treatment, and since they are a fit population, they can undergo a more intensive therapeutic regimen.

Matthew S. Davids, MD, MMSc, Associate Director, Dana-Farber Cancer Institute, Center for Chronic Lymphocytic Leukemia, discusses ibrutinib plus FCR in younger patients with CLL.

Matthew S. Davids, MD, MMSc

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Dr. Davids on the Combination of Ibrutinib and Obinutuzumab in CLL

Dr. Davids on Ibrutinib Plus FCR in Younger Patients With CLL