Genitourinary Cancers | Specialty

The OncLive Genitourinary Cancer condition center page is a comprehensive resource for clinical news and expert insights across genitourinary (GU) malignancies, including renal cell carcinoma, urothelial carcinoma, and prostate cancer. This section features news articles, interviews in written and video format, and podcasts that focus on the evolving treatment paradigm of GU cancers and emerging research.

Long-Term Data Confirm Benefit of Erdafitinib in FGFR-Mutated Urothelial Carcinoma

January 25th 2022

The FGFR TKI erdafitinib continued to provide consistent clinical benefits with a manageable safety profile when used in the second-line treatment of patients with locally advanced or metastatic urothelial carcinoma harboring FGFR alterations.

Dr. Galsky on Clinical Trials That Addressed Key Questions in Urothelial Cancer

January 24th 2022

Matthew Galsky, MD, discusses clinical trials that addressed key questions in urothelial cancer.

Nivolumab/Ipilimumab Showcases Prolonged Treatment-Free Survival in Advanced RCC

January 24th 2022

Over a 42-month period, the combination of nivolumab and ipilimumab induced a longer treatment-free survival compared with sunitinib (Sutent) when used as frontline therapy in patients with advanced renal cell carcinoma.

Dr. Bakouny on Understanding the Biology of Translocation RCC

January 19th 2022

Ziad Bakouny, MD, MSc, discusses understanding the biology of translocation renal cell carcinoma.

Dr. Yentz on Translating Data to Real-World Clinical Practice in RCC

January 18th 2022

Sarah Elizabeth Yentz, MD, discusses translating data to real-world clinical practice in renal cell carcinoma.

Nectin-4 Emerges as a Therapeutic Target in Urothelial Carcinoma and Beyond

January 2nd 2022

Most ongoing clinical trials exploring nectin-4 as a target involve studies of enfortumab vedotin and its potential synergy with immune checkpoint inhibitors in bladder cancer, while several other early-phase studies are testing novel agents in solid tumors.

Dr. Galsky the Evolution of Standard Options in Urothelial Carcinoma

December 23rd 2021

Matthew Galsky, MD, discusses the evolution of standard of care treatment options in urothelial carcinoma.

FDA Approval Sought for Dovitinib for Third-Line Renal Cell Carcinoma

December 22nd 2021

A new drug application has been submitted to the FDA seeking the marketing approval of dovitinib as a potential option in the third-line treatment of patients with renal cell carcinoma.

EU Panel Recommends Adjuvant Pembrolizumab for Select RCC Following Surgery

December 17th 2021

The European Medicines Agency’s Committee for Medicinal Products for Human Use has recommended the approval of single-agent pembrolizumab for use as an adjuvant treatment in adult patients with renal cell carcinoma who are at increased risk of recurrence after nephrectomy, or following nephrectomy and the resection of metastatic lesions.

Enfortumab Vedotin Approaches EU Approval for Locally Advanced or Metastatic Urothelial Cancer

December 17th 2021

The European Medicines Agency’s Committee for Medicinal Products for Human Use has adopted a positive opinion in favor of the approval of enfortumab vedotin as a monotherapy in the treatment of adult patients with locally advanced or metastatic urothelial cancer.

Pembrolizumab Proves Potential as New Standard of Care for RCC in Adjuvant Setting

December 17th 2021

Pembrolizumab demonstrated a statistically significant and clinically meaningful improvement in disease-free survival vs placebo as a postnephrectomy adjuvant therapy in patients with renal cell carcinoma at intermediate-high or high risk of recurrence, and in those who are M1 with no evidence of disease.

FDA Approval Insights: Adjuvant Pembrolizumab in RCC

December 6th 2021

Dr. Choueiri discusses the significance of the FDA approval of pembrolizumab as adjuvant therapy in renal cell carcinoma and key data from the pivotal phase 3 KEYNOTE-564 trial.

Pembrolizumab/Axitinib Improves Outcomes in Japanese mRCC Subgroup

November 30th 2021

The combination of pembrolizumab and axitinib demonstrated comparable activity and safety vs sunitinib in Japanese patients vs the global population of patients with newly diagnosed metastatic renal cell carcinoma enrolled in the phase 3 KEYNOTE-426 trial.

Investigators Set Their Sights on Novel Targets in Genitourinary Malignancies

November 27th 2021

Manojkumar Bupathi, MD, MS, shares the main highlights from the meeting, which centered on frontline, second, and later-line treatment of metastatic urothelial carcinoma and metastatic renal cell carcinoma.

Dr. Choueiri on the FDA Approval of Adjuvant Pembrolizumab in RCC

November 19th 2021

Toni K. Choueiri, MD, discusses the FDA approval of adjuvant pembrolizumab in renal cell carcinoma.

Dr. Nebhan on the Efficacy of Checkpoint Inhibitors in Older Patients With Cancer

November 19th 2021

Caroline Nebhan, MD, PhD, discusses the efficacy of checkpoint inhibitors in older patients with cancer.

Dr. Ramnaraign on Current Treatment Guidelines for First-Line Metastatic RCC

November 18th 2021

Brian Ramnaraign, MD, discusses current first-line treatment guidelines for patients with metastatic renal cell carcinoma.

FDA Approves Adjuvant Pembrolizumab for RCC

November 18th 2021

The FDA has approved pembrolizumab for the adjuvant treatment of patients with renal cell carcinoma who are at intermediate-high or high risk of recurrence following nephrectomy, or following nephrectomy and resection of metastatic lesions.

Subsequent-line Treatment in Advanced RCC Leaves Room for Personalization

November 17th 2021

For patients with advanced clear cell renal cell carcinoma, it will be of utmost importance to recognize the variation in response and type of progression with first-line therapy, the patient’s characteristics and motivations, and the promise of new agents and combinations.

Dr. Bupathi on First-Line Treatment Options for Clear Cell RCC

November 16th 2021

Manojkumar Bupathi, MD, MS, discusses the improvement in first-line treatment options for patients with clear cell renal cell carcinoma.