Genitourinary Cancers | Specialty

The OncLive Genitourinary Cancer condition center page is a comprehensive resource for clinical news and expert insights across genitourinary (GU) malignancies, including renal cell carcinoma, urothelial carcinoma, and prostate cancer. This section features news articles, interviews in written and video format, and podcasts that focus on the evolving treatment paradigm of GU cancers and emerging research.

FDA Approves Adjuvant Nivolumab for High-Risk Urothelial Carcinoma

August 20th 2021

The FDA has approved nivolumab for the adjuvant treatment of patients with urothelial carcinoma who are at high risk of recurrence after undergoing radical resection, irrespective of prior neoadjuvant chemotherapy, nodal involvement or PD-L1 status.

Relapsed/Refractory mRCC: Sequencing Therapy

August 17th 2021

Considerations for how to approach a patient with metastatic renal cell carcinoma previously treated with ipilimumab and nivolumab, followed by nivolumab maintenance.

Treatment Approaches for Relapsed/Refractory mRCC

August 17th 2021

An overview of treatment options for previously treated metastatic renal cell carcinoma.

FDA Issues a Complete Response Letter for Vicineum for High-Risk, BCG-Unresponsive NMIBC

August 16th 2021

The FDA has issued a complete response letter to Sesen Bio regarding its biologics license application for Vicineum for the treatment of patients with Bacillus Calmette-Guérin–unresponsive non–muscle invasive bladder cancer.

Tagawa Takes Stock of Future of Sacituzumab Govitecan in Urothelial Carcinoma

August 16th 2021

Sacituzumab govitecan-hziy, a Trop-2directed antibody-drug conjugate with an SN-38 payload, has carved out a role in the treatment landscape for patients with locally advanced or metastatic urothelial cancer following accelerated approval by the FDA.

FDA Approves Belzutifan for Cancers Linked With Von Hippel-Lindau Disease

August 13th 2021

The FDA has approved belzutifan for the treatment of adult patients with von Hippel-Lindau disease who require therapy for associated renal cell carcinoma, central nervous system hemangioblastomas, or pancreatic neuroendocrine tumors that do not require immediate surgery.

Neoadjuvant Stereotactic Radiation Shows Early Safety, Feasibility in RCC Inferior Vena Cava Tumor Thrombus

August 12th 2021

Neoadjuvant stereotactic radiation followed by radical nephrectomy and thrombectomy is a safe and feasible treatment option for patients with renal cell carcinoma and inferior vena cava tumor thrombus.

FDA Approves Pembrolizumab Plus Lenvatinib for Frontline Advanced RCC

August 11th 2021

The FDA has approved pembrolizumab plus lenvatinib for the frontline treatment of adult patients with advanced renal cell carcinoma.

FDA Grants Priority Review to Adjuvant Pembrolizumab for Post-Nephrectomy RCC

August 10th 2021

The FDA has granted priority review to a new supplemental biologics license application for pembrolizumab as an adjuvant treatment in patients with renal cell carcinoma.

Adjuvant Therapy Approaches for Operable RCC

August 10th 2021

A summary of current therapies and ongoing investigations of adjuvant therapy for patients with operable renal cell carcinoma.

Therapies Under Investigation for Frontline mRCC

August 10th 2021

Novel therapies currently being investigated as frontline options for metastatic renal cell carcinoma.

Checkpoint Inhibitor/TKI Combos Jump RCC Treatment to Next Level

August 9th 2021

Five-year survival rates in renal cell carcinoma are drastically improving due to recent regulatory approvals of combination therapies involving checkpoint blockade and VEGF TKIs.

Pembrolizumab/Lenvatinib Under Evaluation in Frontline Non–Clear Cell RCC

August 4th 2021

Chung-Han Lee, MD, PhD, discusses the goals of the phase 3 KEYNOTE-B61 study and the potential for immunotherapy/TKI combinations in non–clear cell RCC.

Rini Remarks on Remaining Questions With Pembrolizumab/Axitinib in Frontline Advanced Clear Cell RCC

August 4th 2021

At a median follow-up of 42.8 months, frontline pembrolizumab plus axitinib continued to yield improved outcomes over sunitinib in patients with advanced clear cell renal cell carcinoma.

Favorable-Risk mRCC: Treatment Approaches

August 3rd 2021

A panel discussion regarding individual preferences for treating favorable-risk metastatic renal cell carcinoma.

Favorable-Risk mRCC: When to Initiate Therapy

August 3rd 2021

Dr Amishi Y. Shah, of MD Anderson Cancer Center, describes the rationale for active surveillance vs treatment with a novel therapeutic in metastatic renal cell carcinoma.

Pal Provides Perspective on Pivotal Trials in RCC and Prostate Cancer

July 27th 2021

Insights generated from several trials presented during the 2021 ASCO Annual Meeting in renal cell carcinoma illustrate the importance of evaluating checkpoint inhibitors in earlier stages of disease, quality of life, and long-term outcomes, and other data that point to 2 potential new standards of care in prostate cancer.

Intermediate/Poor-Risk mRCC: Treatment Selection

July 27th 2021

Factors oncologists should consider prior to selecting a novel treatment approach for metastatic renal cell carcinoma.

Intermediate/Poor-Risk mRCC: I-O/I-O Vs I-O/TKI Therapy

July 27th 2021

Variables that impact one’s decision to treat metastatic renal cell carcinoma with an immunotherapy-based regimen that includes a targeted agent vs additional immunotherapy.

FDA Issues a Complete Response Letter for Retifanlimab for Squamous Cell Carcinoma of the Anal Canal

July 26th 2021

The FDA has issued a complete response letter to Incyte Corporation stating that it cannot approve the biologics license application for retifanlimab for use in adult patients with locally advanced or metastatic squamous cell carcinoma of the anal canal who have progressed on, or who are intolerant of, platinum-based chemotherapy, in its present form.