Latest Conference Articles

The OncLive® Conference page includes a listing of all conferences covered by OncLive®, including the ASCO, ESMO, SITC, EHA, ASH, and SABCS annual meetings, as well as the Chemotherapy Foundation Symposium and Miami Breast Cancer Conference, among many others. Conference coverage incorporates articles and interviews in written and video format.

Optimal Upfront Lenalidomide/R-CHOP Use Remains Puzzle in DLBCL

June 20th 2019, 12:00am

International Conference on Malignant Lymphoma

Patients with activated B-cell-type diffuse large B-cell lymphoma with a poor prognosis may benefit from frontline treatment with lenalidomide plus standard R-CHOP, according to subgroup data from the phase III ROBUST trial presented at the 2019 International Conference on Malignant Lymphoma.

Dr. Davids on the Phase II CRC043 Trial for Patients With Richter's Transformation

June 19th 2019, 11:55pm

International Conference on Malignant Lymphoma

Matthew S. Davids, MD, MMSc, associate director, Center for Lymphocytic Leukemia, physician, Dana-Farber Cancer Institute, and assistant professor of medicine, Harvard Medical School, discusses the use of the BCL‐2 inhibitor, venetoclax (Venclexta) with dose-adjusted infused etoposide, doxorubicin, and cyclophosphamide with vincristine, prednisone, and rituximab (R-EPOCH) to treat patients with Richter

Dr. Vose on Acalabrutinib/Pembrolizumab Combo in DLBCL

June 19th 2019, 11:37pm

International Conference on Malignant Lymphoma

Julia M. Vose, MD, professor and chief in the Division of Oncology/Hematology at University of Nebraska Medical Center discusses the rationale for the phase I/II trial of acalabrutinib (Calquence) plus pembrolizumab (Keytruda) in relapsed/refractory diffuse large B-cell lymphoma (DLBCL).

Maintenance Therapy Remains Challenging Strategy in DLBCL

June 19th 2019, 10:51pm

International Conference on Malignant Lymphoma

Maintenance therapy with rituximab did not lead to an improvement in disease-free survival among patients who achieved complete remission following 4 cycles of R-CHOP.

Acalabrutinib Monotherapy Safe, Significantly Improves PFS in Relapsed/Refractory CLL

June 16th 2019, 10:42pm

European Hematology Association Congress

Among the most highly anticipated study results to be presented during the 2019 European Hematology Association Congress were those of the phase III ASCEND trial, which investigated the use of acalabrutinib monotherapy in patients with previously-treated chronic lymphocytic leukemia.

Ibrutinib Significantly Prolongs PFS in Early-Stage CLL

June 16th 2019, 10:02pm

European Hematology Association Congress

Ibrutinib monotherapy significantly improved event- and progression-free survival compared with placebo in treatment-naïve patients with early-stage, asymptomatic chronic lymphocytic leukemia.

Phase III BELLINI Data Showcase Safety Concerns With Venetoclax in Multiple Myeloma

June 16th 2019, 9:50pm

European Hematology Association Congress

Despite promising progression-free survival and response data with venetoclax in combination with bortezomib and dexamethasone, an increased number of deaths due to infection in the experimental arm marred overall survival findings in patients with relapsed/refractory multiple myeloma.

Dr. O'Brien on the Phase III ASCEND Trial in CLL

June 16th 2019, 7:46pm

European Hematology Association Congress

Susan M. O’Brien, MD, associate director for Clinical Services, Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, discusses the phase III ASCEND trial in chronic lymphocytic leukemia.

New Macrophage Immune Checkpoint Strategy Shows Promise in AML and MDS

June 16th 2019, 2:41am

European Hematology Association Congress

Hu5F9-G4 (5F9), a first-in-class antibody targeting CD47, used as monotherapy or in combination with standard azacitidine was well tolerated and provided deep and durable responses in patients with acute myeloid leukemia or myelodysplastic syndrome, according to findings from a phase IB study presented at the 2019 European Hematology Association Congress.

Dr. Roboz on the QuANTUM-R Trial in AML

June 16th 2019, 12:32am

European Hematology Association Congress

Gail Roboz, MD, a professor of medicine and director of the Clinical and Translational Leukemia Program at Weill Cornell MedicineNewYork-Presbyterian Hospital, discusses the QuANTUM-R trial, which evaluated quizartinib versus chemotherapy in patients with relapsed/refractory FLT3-mutant acute myeloid leukemia.

Dr. Tedeschi on Frontline Ibrutinib for Older Patients With CLL

June 16th 2019, 12:21am

European Hematology Association Congress

Alessandra Tedeschi MD, Department of Hematology, Azienda Ospedaliera Niguarda Ca' Granda in Milan, Italy, discusses the long-term findings of the phase III RESONATE-2 trial during the 2019 European Hematology Association Congress.

Frontline Venetoclax/Obinutuzumab Combo Emerges as Treatment Option for CLL With CKT

June 15th 2019, 10:37pm

European Hematology Association Congress

Othman Al-Sawaf, MD, discusses findings from the CLL14 trial, the rationale for exploring this proposed combination, and shares his thoughts on the emerging treatment paradigms in chronic lymphocytic leukemia.

Addition of Rigosertib Improves Azacitidine Benefit in Patients With Higher-Risk MDS

June 15th 2019, 8:17pm

European Hematology Association Congress

The combination of rigosertib and azacitidine demonstrated improved response rates over single-agent azacitidine in patients with higher-risk myelodysplastic syndrome, including patients naïve to a hypomethylating (HMA) agent and those who were refractory to HMAs.

Second-Generation FLT3 Inhibitors Are Future of Relapsed/Refractory FLT3-Mutant AML Treatment

June 15th 2019, 1:48am

European Hematology Association Congress

Naval G. Daver, MD, discusses the data that support quizartinib so far, ongoing investigations with this drug in the frontline setting, and the potential for the agent to be approved by the FDA.

Frontline Ibrutinib Showcases Long-Term OS Benefit in Older Patients With CLL

June 15th 2019, 1:33am

European Hematology Association Congress

Frontline therapy with ibrutinib was successfully administered for more than 60 months in patients with chronic lymphocytic leukemia aged 65 years and older and provided improved progression-free and overall survival compared with chlorambucil.

Imetelstat Provides Durable Transfusion Independence in Lower-Risk Relapsed/Refractory MDS

June 14th 2019, 8:20pm

European Hematology Association Congress

Imetelstat treatment may allow patients with debilitating anemia due to myelodysplastic syndrome to remain transfusion-free for extended periods of time.

Elotuzumab Triplet Continues to Show Survival Benefit in Relapsed/Refractory Myeloma

June 14th 2019, 7:32pm

European Hematology Association Congress

The triplet regimen of elotuzumab plus pomalidomide and dexamethasone led to a 46% reduction in the risk of death compared with pomalidomide/dexamethasone alone in patients with relapsed/refractory multiple myeloma, according to updated findings of the phase II ELOQUENT-3 trial.

Dr. Rule on the MabCute Study in Indolent Non-Hodgkin Lymphoma

June 14th 2019, 5:36pm

European Hematology Association Congress

Simon Rule, MD, PhD, Plymouth University Medical School, discusses results of the phase III MabCute study evaluating subcutaneous rituximab as maintenance after standard subcutaneous rituximab induction and maintenance in patients who have relapsed or refractory indolent non-Hodgkin lymphoma.

Dr. Chari on the INSIGHT MM Study on Multiple Myeloma

June 14th 2019, 5:21pm

European Hematology Association Congress

Ajai Chari, MD, Icahn School of Medicine at Mount Sinai, discusses INSIGHT MM (NCT02761187), the largest global, prospective, non-interventional, observational study on multiple myeloma to date.

Larotrectinib Effective in TRK+ Pediatric Cancers and CNS Tumors

June 7th 2019, 11:12pm

ASCO Annual Meeting

The efficacy of larotrectinib is supported in distinct patient populations with TRK fusion cancer—specifically pediatric patients and adult or pediatric patients with brain metastases or primary central nervous system tumors.