Advancements in the Management of Gynecological Cancers: ESMO 2024 - Episode 4

Emerging Combinations in Maintenance Therapy for Ovarian Cancer

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Panelists discuss strategies to address PARP inhibitor (PARPi) resistance in ovarian cancer, including emerging combinations like gotistobart + pembrolizumab from the PRESERVE-004 trial, insights from the SOPRANO trial on managing oligometastases or oligoprogression, and approaches to mitigate or manage common adverse events associated with PARPi maintenance therapy.

Video content above is prompted by the following:

What new maintenance strategies (eg, immunotherapy combination therapy or hormonal maintenance therapy) are being explored for advanced/metastatic disease?

  • Rucaparib + nivolumab
  • Atezolizumab + bevacizumab
  • Olaparib + cediranib
  • Where do these fit in the treatment paradigm?
  • In which patients may you consider these combination approaches?