Updates on HER2-Directed ADCs Across Solid Tumors - Episode 4

Emerging Data from ASCO 2024 in HER2-low: DESTINY-Breast06

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Dr Gadi leads a discussion on recent data on the treatment of HER2-low tumors, including ASCO updates on the DESTINY-Breast06 trial.

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    EP. 1: Assessing HER2 Status Across Tumor Types
    EP. 2: ADCs Targeting HER2+ Breast Cancer
    EP. 3: ADCs Targeting HER2+ Gynecologic Cancers
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    EP. 4: Emerging Data from ASCO 2024 in HER2-low: DESTINY-Breast06
    EP. 5: ADCs Targeting GI Cancers
    EP. 6: ADCs Targeting HER2+ Lung Cancer
    EP. 7: Impact of ADCs on Brain Metastases
    EP. 8: ADCs Targeting HER2+ GU Cancers
    EP. 9: Overcoming Challenges of Testing for HER2-low Across Solid Tumor Types
    EP. 10: The Potential Role for HER2-Targeted ADCs in Earlier Treatment Lines
    EP. 11: Managing ILD and Pneumonitis Risk From ADCs
    EP. 12: Managing Toxicities in Short- and Long-Term Treatment with ADCs
    EP. 13: Managing Hematologic AEs Associated with ADC Treatments
    EP. 14: Management of Emetogenicity of Antibody-Drug Conjugates
    EP. 15: ADC Sequencing
    EP. 16: Emerging ADCs in Development
    EP. 17: Insights on T-DXd Approval as Tumor-Agnostic HER2-Directed Therapy
    EP. 18: The Future for HER2-Directed ADCs
    EP. 19: Key Takeaways and Closing Thoughts on ADCs

    Video content above is prompted by the following:

    • Can you please offer an overview of the primary results from the DESTINY-PanTumor02 trial (Meric-Bernstam_J Clin Oncol_2024), specifically in regard to each of the following:
      • cervical
      • ovarian cancers
      • endometrial
        • STATICE trial results (Nishikawa J Clin Oncol 2023)
        • What is the potential for DB-1303 in endometrial cancer (Moore_J Clin Oncol_2023)
    • Where in the treatment sequencing do you expect HER2-direct ADCs to fit?
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