Resection Should be Considered for Residual Non-Retroperitoneal Disease in Post-Chemo NSGCTs - Episode 4

King Describes Unmet Needs and the Role of Surgical Resection in Residual Non-RP Testicular Cancer

Dr King discusses the need for improved guidance when determining the appropriate management strategy for patients with residual nonretroperitoneal testicular cancer and findings from a study on the association between the presence of teratoma in the primary orchiectomy and the rate of teratoma in this disease.

EP. 1: Dr King on Teratoma in Residual Nonretroperitoneal Disease After Chemotherapy for Testicular Cancer
EP. 2: Resection Should be Considered for Residual Non-Retroperitoneal Disease in Post-Chemo NSGCTs
EP. 3: Further Research Needed to Inform the Management of Post-Chemo Residual Nonretroperitoneal Disease in Testicular Cancer
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EP. 4: King Describes Unmet Needs and the Role of Surgical Resection in Residual Non-RP Testicular Cancer

Welcome to OncLive On Air®! I’m your host today, Courtney Flaherty.

OncLive On Air® is a podcast from OncLive®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive® covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, we had the pleasure of speaking with Jennifer M. King, MD, on findings from a retrospective study on the association between the presence of teratoma in the primary orchiectomy and the rate of teratoma in residual nonretroperitoneal (non-RP) disease post-chemotherapy for nonseminomatous germ cell tumors. Dr King is an assistant professor of clinical medicine in the Department of Medicine in the Division of Hematology/Oncology at Indiana University (IU) School of Medicine in Indianapolis and a physician-scientist at the IU Melvin and Bren Simon Comprehensive Cancer Center in Indianapolis.

Using the Indiana University testicular cancer database, the retrospective analysis revealed that both groups of patients had comparable rates of teratoma or active germ cell tumor in residual non-RP disease. Fifty-five percent of patients with teratoma in the primary tumor site (n=75) had one or more post-chemotherapy non-RP teratomatous elements in their residual disease vs 17% of patients without teratoma in the primary tumor (n = 59). Moreover, 56% of patients without teratoma in the primary tumor had an active germ cell tumor at the time of surgical resection vs 31% of those with primary tumor teratoma.

In our exclusive interview, Dr King discussed the need for improved guidance when determining the appropriate management strategy in residual non-RP testicular cancer, the methodology and patient population included in this retrospective review, and how the presence or absence of teratoma in the primary tumor should not preclude surgical resection in this patient population.

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