Novel Breakthroughs in Management of Pediatric Low-Grade Glioma (pLGG) - Episode 5

Ongoing clinical trials for frontline treatment of non-V600E-specific pLGG tumors

The panel reviews ongoing clinical trials for non-BRAF V600E pediatric low-grade gliomas (pLGG), specifically highlighting the Phase III ACNS1831 and Phase III ACNS1833 studies, discussing their objectives, designs, and potential implications for future treatment strategies.

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    EP. 1: Overview of pLGG presentation and categorization
    EP. 2: Molecular Characterization of pLGG
    EP. 3: Less Common Molecular Alterations in pLGG and Testing Recommendations
    EP. 4: Standard of care for frontline treatment of non-V600E-specific pLGG tumors
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    EP. 5: Ongoing clinical trials for frontline treatment of non-V600E-specific pLGG tumors
    EP. 6: Current Treatment of Patients with NF1 pLGG
    EP. 7: Standard of Care Pptions Specific for Frontline Treatment of BRAF V600E-Mutated pLGG
    EP. 8: Treatment Considerations for Progressive pLGG
    EP. 9: Radiation and Targeted Therapies for Progressive pLGG
    EP. 10: The Role of Tovorafenib in Treatment of Progressive pLGG
    EP. 11: Clinical Trials to Increase Treatment Options in the Progressive Setting
    EP. 12: Clinical scenario 1 - BRAFKIAA-1549 fusion
    EP. 13: Alternatives and Considerations for Clinical Scenario 1
    EP. 14: Clinical Scenario 2 - BRAFV600E
    EP. 15: Potential Adverse Events With Targeted Therapies
    EP. 16: Clinical Insights: Looking Forward for pLGG
    • What are some ongoing Phase II/III trials in this space?
      • Phase II Vinblastine +/- Bevacizumab in chemotherapy naïve pLGG (NCT02840409)
      • Phase III ACNS1831: Selumetinib vs carboplatin/vincristine in NF1 pLGG (NCT03871257)
      • Phase III ACNS1833: Selumetinib vs carboplatin/vincristine in non-V600E and non-NF1 pLGG (NCT04166409)

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