The key opinion leaders explore the various first-line combination treatment options for advanced renal cell carcinoma, including immuno-oncology plus immuno-oncology (IO+IO) and immuno-oncology plus tyrosine kinase inhibitor (IO+TKI) approaches, while also considering the optimal sequencing of treatments to maximize patient benefit.
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What are the available first-line combination options for advanced RCC?
Please discuss your rationale for choosing between IO+IO and IO+TKI approaches and review these data: Network meta-analysis (NMA) – Grunwald, et al. ASCO GU 2024. Abstract 482 –len + pembro vs other 1L treatments in advanced RCC
How do you approach treatment selection in the frontline setting?
What factors do you consider when choosing treatment?
Which patients do you choose len-pembro versus axi-pembro versus cabo-nivo?