Seth M. Pollack, MD

Articles

Post-Imatinib Progression: Decision Factors and Treatment Options

April 7th 2025

Experts discuss key factors influencing decision-making when patients with advanced gastrointestinal stromal tumors (GIST) progress on imatinib, reviewing standard second-line options, considerations for increasing imatinib dosing vs switching to a different tyrosine kinase inhibitor (TKI), and clinical or radiographic patterns that guide therapy changes or dose escalation at progression.

Monitoring Tumor Heterogeneity and Detecting Resistance

April 7th 2025

Experts discuss the tools available to monitor tumor heterogeneity and detect resistance, examining the reliability of current testing methods, differences in molecular testing for newly diagnosed metastatic patients vs those who have progressed, the role of liquid biopsy compared to traditional tissue biopsy, and how these test results inform risk assessment and clinical decision-making.

Biological Mechanisms of GIST Resistance and Tumor Heterogeneity

March 31st 2025

Experts discuss the biological mechanisms of resistance in gastrointestinal stromal tumors (GIST), differentiating between primary and secondary resistance, and explore how tumor heterogeneity evolves throughout treatment, with implications for long-term management and treatment strategies.

Optimizing TKI Selection and Sequencing Strategies in Advanced GIST Beyond First-Line Therapy

March 31st 2025

Experts discuss optimizing TKI selection and sequencing strategies for advanced gastrointestinal stromal tumors (GIST) beyond first-line therapy, focusing on the latest clinical data, molecular characterization, and insights from recent trials to guide treatment decisions.

Dr. Pollack on the Future Treatment Landscape for Sarcoma

April 8th 2017

Seth M. Pollack, assistant professor, Division of Oncology, University of Washington, and attending physician, Seattle Cancer Care Alliance, discusses the future treatment paradigm of soft tissue sarcoma.

Dr. Pollack on the Potential Impact of Radiomics on the Sarcoma Treatment Landscape

February 3rd 2017

Seth M. Pollack, MD, assistant professor, Division of Oncology, University of Washington, and attending physician, Seattle Cancer Care Alliance, discusses the potential impact that radiomics could have on the treatment landscape of sarcoma.

Dr. Pollack on the Role of Radiomics in Sarcoma

December 13th 2016

Seth M. Pollack, assistant professor, Division of Oncology, University of Washington, and attending physician, Seattle Cancer Care Alliance, discusses the role of radiomics in the treatment landscape of sarcoma.

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