My Treatment Approach Beyond the First-Line: Expert Insights on Evidence-Driven TKI Selection and Sequencing in Advanced GIST - Episode 2

Biological Mechanisms of GIST Resistance and Tumor Heterogeneity

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Experts discuss the biological mechanisms of resistance in gastrointestinal stromal tumors (GIST), differentiating between primary and secondary resistance, and explore how tumor heterogeneity evolves throughout treatment, with implications for long-term management and treatment strategies.

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    EP. 1: Optimizing TKI Selection and Sequencing Strategies in Advanced GIST Beyond First-Line Therapy
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    EP. 2: Biological Mechanisms of GIST Resistance and Tumor Heterogeneity

    Video content above is prompted by the following:

    • Let’s start with the fundamentals of resistance in GIST. Could you explain the biological mechanisms of resistance in GIST? Could you differentiate between primary and secondary resistance in GIST and explain how each impacts your treatment approach?
    • How does tumor heterogeneity evolve throughout treatment course, and what implications does this have for long-term management?

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