My Treatment Approach Beyond the First-Line: Expert Insights on Evidence-Driven TKI Selection and Sequencing in Advanced GIST

Experts discuss the latest clinical data on tyrosine kinase inhibitor (TKI) therapy for gastrointestinal stromal tumors (GIST), focusing on optimizing treatment selection and sequencing strategies for patients progressing beyond first-line therapy, with insights into how molecular characterization and recent clinical trials inform decisions across multiple treatment lines, illustrated through patient case discussions.

EP. 1: Optimizing TKI Selection and Sequencing Strategies in Advanced GIST Beyond First-Line Therapy

March 31st 2025

Experts discuss optimizing TKI selection and sequencing strategies for advanced gastrointestinal stromal tumors (GIST) beyond first-line therapy, focusing on the latest clinical data, molecular characterization, and insights from recent trials to guide treatment decisions.

EP. 2: Biological Mechanisms of GIST Resistance and Tumor Heterogeneity

March 31st 2025

Experts discuss the biological mechanisms of resistance in gastrointestinal stromal tumors (GIST), differentiating between primary and secondary resistance, and explore how tumor heterogeneity evolves throughout treatment, with implications for long-term management and treatment strategies.

EP. 3: Monitoring Tumor Heterogeneity and Detecting Resistance

April 7th 2025

Experts discuss the tools available to monitor tumor heterogeneity and detect resistance, examining the reliability of current testing methods, differences in molecular testing for newly diagnosed metastatic patients vs those who have progressed, the role of liquid biopsy compared to traditional tissue biopsy, and how these test results inform risk assessment and clinical decision-making.

EP. 4: Post-Imatinib Progression: Decision Factors and Treatment Options

April 7th 2025

Experts discuss key factors influencing decision-making when patients with advanced gastrointestinal stromal tumors (GIST) progress on imatinib, reviewing standard second-line options, considerations for increasing imatinib dosing vs switching to a different tyrosine kinase inhibitor (TKI), and clinical or radiographic patterns that guide therapy changes or dose escalation at progression.

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