EHA 2024: Updates in the Treatment of CLL    - Episode 14

Navigating BTKi Resistance in CLL with Findings from ELEVATE-RR and ALPINE Studies: Sequencing Approach and Potential Role for Testing

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Key opinion leaders examine recent evidence on acquired BTK inhibitor resistance in chronic lymphocytic leukemia and analyze its implications for treatment sequencing decisions in clinical practice.

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    EP. 1: Introducing the Expert Panel on CLL Treatment Updates Live at EHA 2024
    EP. 2: Testing Practices and Role of High-risk Features to Decision Making in Newly Diagnosed CLL
    EP. 3: Frontline BTKi Selection
    EP. 4: Dr Parrondo’s Frontline CLL Treatment Approach for Pre-existing HTN and Afib
    EP. 5: Dr Lamanna Reviews Study Data for 1L Doublet Therapy or Triplet Therapy
    EP. 6: Dr Danilov Reviews EHA 2024 Data on the Role of 1L Triplet Therapy in CLL
    EP. 7: EHA 2024 Review of Ongoing Trials Evaluating BCL2i/BTKi Combination Approaches
    EP. 8: Navigating Treatment Approaches for R/R CLL
    EP. 9: How Experts View MAIC Data That was Presented at EHA 2024
    EP. 10: BTKi Intolerance in Real-world Practice & Management Strategy
    EP. 11: Applying EHA 2024 Data to Switching and Sequencing Treatments for CLL & Impact of Toxicities
    EP. 12: Approach to Hypertension Management With BTKi Treatment
    EP. 13: Dr Parrondo shares Approach to Managing BTKi Treatment-Related Afib
    Now Viewing
    EP. 14: Navigating BTKi Resistance in CLL with Findings from ELEVATE-RR and ALPINE Studies: Sequencing Approach and Potential Role for Testing
    EP. 15: Experts Review Pirtobrutinib Clinical Data and Share its Utilization in Practice
    EP. 16: TRANSCEND CLL 004 Data Review and its Impact on Future Treatment Practices
    EP. 17: EHA 2024 Updated Data on BTKi Degraders as Emerging Novel Agents in R/R CLL
    EP. 18: Dr Parrando Reviews EHA 2024 Data on BTKi Degrader, BGB-16673
    EP. 19: Dr Lamanna Shares Perspectives on EHA 2024 Data for the 2G BCL2 Inhibitors in R/R CLL
    EP. 20: Review of Data from EHA 2024 of Emerging Novel Bispecific Antibodies
    EP. 21: Clinical Pearls and Impacts to Practice from EHA 2024
    • Briefly discuss the latest evidence surrounding acquired BTKi resistance in CLL. What clinical insights do recent data provide?

    Dr Coombs to Group:What implications may these findings have on treatment sequencing? Is there a potential role of testing for acquired mutations upon disease progression?

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