Panelists discuss how treatment decisions for advanced non–small cell lung cancer (NSCLC) without actionable mutations depend on factors like PD-L1 status, histology (eg, squamous [SQ]), and biomarkers like STK11/KEAP1. Chemotherapy may be added based on individual patient factors, with promising advancements expected in 2025.
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How do you select between mono immunotherapy (IO) and dual IO therapy in patients with advanced NSCLC and no actionable mutations?
In which patients do you consider the addition of chemotherapy?
How does PD-L1 status influence your decision?
What is your preferred management strategy for patients with SQ histology? STK11 or KEAP1? What data influence your treatment approach?
What advancements in lung cancer from 2024 will have the most significant impact on your clinical practice in 2025?
What do you see as the greatest treatment gaps and unmet needs in the management of advanced NSCLC, and what are the most promising opportunities for future advancements?